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The UPWARD project is a large randomized controlled trial of an online mindfulness program called “Mindful Mood Balance for Moms.” Developed with leading experts in mindfulness and with new and expectant moms, this program is delivered digitally in an eight-session format that replicates the core elements of in-person mindfulness training. Participants are invited to log on to the program every day and to access personalized coaching via telephone during the 12-week program. With our partners at the Massachusetts General Hospital’s Center for Women’s Mental Health, we are actively enrolling 500 pregnant women from all around the country to participate in the study, comparing the impact of the Mindful Mood Balance for Moms program relative to usual care in communities on mental health outcomes.